Clinical trials

A clinical trial compares the effects of 1 treatment with another. It may involve patients, healthy people, or both.

How do I take part in a clinical trial?

You can ask your doctor or a patient organisation if they know of any clinical trials that you may be eligible to join.

You can also search for information on a number of websites and register your interest in taking part in research.

Be Part of Research website

The Be Part of Research website has information about clinical trials and other research from several different UK registers.

You can also search the Be Part of Research site to find trials relevant to you, and you can contact researchers yourself.

World Health Organization (WHO) International Clinical Trials

The WHO International Clinical Trials Registry Platform (ICTRP) website provides access to clinical trials in countries all around the world.


For some health conditions, you can find out about clinical trials from the websites of charities.

Examples are:

Why join a clinical trial?

Clinical trials help doctors understand how to treat a particular illness. It may benefit you, or others like you, in the future.

If you take part in a clinical trial, you may be one of the first people to benefit from a new treatment.

But there's also a chance that the new treatment turns out to be no better, or worse, than the standard treatment.

To hear other people's experiences of taking part in a clinical trial, visit the website

Will I get paid?

Some clinical trials offer payment, which can vary depending on what's involved and expected from you.

Some trials do not offer payment and just cover your travel expenses.

It's important to find out about the inconvenience and risks involved before you sign up, and to carefully weigh up whether it's worth it.

Bear in mind:

What happens in a clinical trial?

Testing a new medicine

All clinical trials of new medicines go through a series of phases to test whether they're safe and whether they work.

The medicines will usually be tested against another treatment called a control.

This will either be a dummy treatment (a placebo) or a standard treatment already in use.

Phase 1 trials:

Phase 2 trials:

Phase 3 trials:

Phase 4 trials:

Control groups, randomisation and blinding

If you take part in a clinical trial, you'll usually be randomly assigned to either the:

While the treatments are different in the 2 groups, researchers try to keep as many of the other conditions the same as possible.

For example, both groups should have people of a similar age, with a similar proportion of men and women, who are in similar overall health.

In most trials, a computer will be used to randomly decide which group each patient will be allocated to.

Many trials are set up so nobody knows who's been allocated to receive which treatment.

This is known as blinding, and it helps reduce the effects of bias when comparing the outcomes of the treatments.

What should I know before I sign up?

When you express interest in a trial, a doctor or nurse is likely to tell you something about it in person.

You'll also be given some printed information to take away.

You may come back with some questions you feel have not been answered.

General questions

Practical questions

Things to weigh up

As with any treatment, you cannot be sure of the outcome.

You may be given a new treatment that turns out not to be as effective as the standard treatment.

Also, it's possible you'll experience unexpected side effects.

And bear in mind that you may have to visit your place of treatment more often, or have more tests, treatments or monitoring, than you would if you were receiving the standard treatment in usual care.

Leaving a trial

You may decide to stop taking part in a trial if your condition is getting worse or you feel the treatment is not helping you.

You can also choose to leave at any point without giving a reason and without it affecting the care you receive.


At the end of the trial, the researchers should publish the results and make them available to anyone who took part and wanted to know the results.

If the researchers do not offer you the results and you want to know, ask for them.

Some research funders, such as the National Institute for Health Research (NIHR), have websites where they publish the results of the research they have supported.

Visit the NIHR website to find out more

How are trials regulated and judged ethical?

Before a clinical trial of a new medicine can begin, a government agency called the Medicines and Healthcare products Regulatory Agency (MHRA) needs to review and authorise it.

The MHRA also inspects sites where trials take place to make sure they're conducted in line with good clinical practice.

Visit the GOV.UK website to read about the MHRA

The Health Research Authority (HRA) works to protect and promote the interests of patients and the public in health research. 

It's responsible for research ethics committees up and down the country.

All medical research involving people in the UK, whether in the NHS or the private sector, first has to be approved by an independent research ethics committee.

The committee protects the rights and interests of the people who will be in the trial.

Find out more on the HRA website

How are trial results used to improve treatment?

Clinical trials can help:

Many clinical trials are designed to show whether new medicines work as expected.

These results are sent to the MHRA, which decides whether to allow the company making the medicine to market it for a particular use.

Licensing a treatment

If research has identified a new medicine, the MHRA must license it before it can be marketed.

Licensing shows a treatment has met certain standards of safety and effectiveness.

Safety must be monitored carefully over the first few years of a newly licensed treatment.

This is because rare side effects that were not obvious in clinical trials may show up for the first time.

In England and Wales, the National Institute for Health and Care Excellence (NICE) decides whether the NHS should provide treatments.

Find out more on the NICE website

Where can I find results from trials that are relevant to me?

The results of clinical trials are usually published in specialist medical journals and online libraries of evidence.

Some of the most well-known examples are:

You can use a search engine such as Google to look for articles and read summaries (abstracts).

But you cannot usually see the full articles without a subscription to the journal.

Also, research papers are not written in plain English and often use many medical, scientific and statistical terms. They can be very difficult to understand.

Page last reviewed: 22 December 2022
Next review due: 22 December 2025