Erythema multiforme

Erythema multiforme is a skin reaction that can be triggered by an infection or some medicines. It's usually mild and goes away in a few weeks.

There's also a rare, severe form that can affect the mouth, genitals and eyes and can be life-threatening. This is known as erythema multiforme major.

Erythema multiforme mainly affects adults under 40, although it can happen at any age.

Symptoms of erythema multiforme

Most people with erythema multiforme will just have a rash, but other symptoms can sometimes occur.


The rash starts suddenly and develops over a few days. It tends to start on the hands or feet, before spreading to the limbs, upper body and face.

The rash:

In more severe cases, the patches may join together to form large, red areas that may be raw and painful.

Other symptoms

Additional symptoms of erythema multiforme can include:

These symptoms are more common in erythema multiforme major or a similar condition called Stevens-Johnson syndrome.

When to get medical advice

See a GP as soon as possible if you think you or your child may have erythema multiforme.

A GP may be able to diagnose it just by looking at the rash, but they can refer you to a skin specialist (dermatologist) if they're not sure.

If erythema multiforme major or Stevens-Johnson syndrome is suspected, you'll be referred to hospital immediately because these conditions can be serious.

If you're unable to see a GP, call NHS 111 or go to

Causes of erythema multiforme

The cause of erythema multiforme is often unclear, but some cases are the result of a reaction to an infection or medicine.

The condition cannot be passed from person to person.


Most cases are caused by a viral infection – often the herpes simplex (cold sore) virus. This virus usually lies inactive in the body, but it can become reactivated from time to time.

Some people will get a cold sore a few days before the rash starts.

Erythema multiforme can also be triggered by mycoplasma bacteria, a type of bacteria that sometimes cause chest infections.


Some medicines can occasionally cause the more severe form of erythema multiforme. Possible medicine triggers include:

Treatments for erythema multiforme

Treatment aims to tackle the underlying cause of the condition, relieve your symptoms and stop your skin becoming infected.

Your doctor may recommend:

More severe cases may be treated in hospital with:

Complications of erythema multiforme

Most people with erythema multiforme make a full recovery within a few weeks. There are usually no further problems and the skin heals without scarring.

There is a risk the condition could come back at some point, especially if it was caused by the herpes simplex virus.

You may be given antiviral medicine to prevent attacks if you experience them frequently.

In severe cases, possible complications can include:

Page last reviewed: 13 September 2019
Next review due: 13 September 2022