Mirabegron

About mirabegron

Mirabegron is a medicine that eases the symptoms of overactive bladder. It does not treat your condition.

It helps with symptoms such as:

Mirabegron works by relaxing the muscles around your bladder. This means your bladder can hold more liquid and reduces your need to pee as often or as urgently.

This medicine is only available on prescription.

It comes as slow-release tablets (called "modified release" or "prolonged release"). This means the tablets release mirabegron slowly and evenly throughout the day.

Key facts

Who can and cannot take mirabegron

Mirabegron can be taken by adults (aged 18 years and over).

It is not suitable for everyone. To make sure it's safe for you, tell your doctor or pharmacist before starting mirabegron if you:

How and when to take mirabegron

How much will I take?

You'll usually take mirabegron once a day. It does not matter what time you take this medicine as long as it is at the same time each day.

Swallow the tablets whole with a drink of water. Do not chew or crush them.

You can take mirabegron with or without food.

Mirabegron comes as 25mg and 50mg tablets.

The usual dose is 50mg, taken once a day.

If you have a kidney or liver problem, your doctor may recommend a lower dose of 25mg taken once a day.

What if I forget to take it?

If you forget to take your medicine, take it as soon as you remember unless the next dose is due in less than 6 hours. In this case skip the missed dose and take your next one at the usual time.

Do not take a double dose to make up for a missed dose.

If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

What if I take too much?

If you take too much mirabegron, it is unlikely to harm you.

If you take an extra dose by mistake, you might get some of the common side effects, such as increased heart rate, or headache and dizziness.

Contact 111 now for advice if:

You've taken more than your usual dose of mirabegron and:

  • you're having side effects
  • you're worried

Call 111 or go to 111.nhs.uk

Side effects of mirabegron

Common side effects

Like all medicines, mirabegron can cause side effects in some people, but many people have no side effects or only minor ones.

Side effects often improve as your body gets used to the medicine.

Common side effects happen in more than 1 in 100 people. They are usually mild and shortlived.

Talk to your doctor or pharmacist if the side effects bother you or do not go away:

Serious side effects

Serious side effects are rare and happen in less than 1 in 1,000 people.

Contact 111 for advice if:

  • you have problems emptying your bladder completely, or problems starting to pee
  • you have irritated eyes; red or swollen eyelids
  • you get small spots on your skin that are purple but not itchy

Call 999 or go to A&E if:

  • you have chest pain, a very severe headache, or difficulty breathing

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to mirabegron.

Call 999 or go to A&E if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of mirabegron. For a full list see the leaflet inside your medicines packet.

You can report any suspected side effect to the UK safety scheme.

How to cope with side effects

What to do about:

Pregnancy and breastfeeding

Mirabegron and pregnancy

Mirabegron is not usually recommended in pregnancy. There's not enough information available to say whether it's safe or not to take this medicine during pregnancy.

There may be other medicines for treating urinary symptoms that are safer for you.

If you're pregnant or trying to get pregnant, talk to your doctor about the benefits and possible risks of taking mirabegron.

Mirabegron and breastfeeding

There's not a lot of information about the safety of mirabegron when breastfeeding.

Mirabegron is likely to pass into your breast milk and so it may cause problems for your baby.

Talk to your doctor, as other medicines for urinary symptoms might be better while you're breastfeeding.

Tell your doctor if you're:

  • pregnant
  • trying to get pregnant
  • breastfeeding

For more information about what to do about bladder problems during pregnancy, read this leaflet about treating urinary incontinence on the Best Use of Medicines in Pregnancy (BUMPs) website.

Cautions with other medicines

Taking mirabegron with herbal remedies and supplements

Mirabegron may affect the way other medicines work, and other medicines may affect how mirabegron works.

Tell your pharmacist or doctor if you're taking:

There's very little information about taking mirabegron with herbal remedies and supplements. These remedies are not tested in the same way as medicines.

Important

For safety, tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies and supplements.

Common questions about mirabegron

How does mirabegron work? How long does it take to work? How long will I take it for? Can I take it for a long time? Can I take painkillers with mirabegron? What will happen if I stop taking it? How does mirabegron compare with other medicines for bladder problems? Can I drink alcohol with mirabegron? Is there any food or drink I need to avoid? Will mirabegron affect my contraception? Will mirabegron affect my fertility? Can I drive or ride a bike? Are there other treatments for overactive bladder?